Giles Mutseyekwa was a Zimbabwean politician and member of the Movement for Democratic Change (MDC) led by Morgan Tsvangirai . He was a co-Minister of Home Affairs in the Government of National Unity (GNU) which was established in 2009 and ended in 2013.

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Mutseyekwa, a retired major, died on the 27th of June 2022. He was MDC-T deputy national chairperson at the time of his death.