Isabel Mwonzora is the firstborn daughter of Douglas Mwonzora.
Isabel has a sister named Bertha.
Isabel is a law graduate.
Isabel told NewZimbabwe.com that she joined politics at 20 years of age.
In 2018, Isabel joined a faction of the MDC-T that at the time was being led by Thokozani Khupe. Her father was still part of Nelson Chamisa and the MDC Alliance. Isabel Mwonzora was elected MDC-T (Khupe) youth assembly secretary-general. Speaking on her decision to join Khupe at the time, Isabel said:
"But as time went on we began to differ on many things. Right now, I have decided to join the MDC-T and leaving the MDC Alliance because of the issue of constitutionalism."
- Nkosana Dlamini, FAMILY & POLITICS: Mwonzora’s daughter on ditching dad and Chamisa for Khupe, NewZimbabwe.com, Published: April 30, 2021, Retrieved: April 28, 2021