Mwenezi is one of the districts in Masvingo province. It is divided by the Mwenezi River and the A4 highway, the main road that connects the town of Beitbridge, on the border with South Africa, to Masvingo.
Mwenezi derives its name from the Mwenezi River, which provides irrigation water to the sugarcane plantations in and around the Rutenga Business Center.Although the police station is located along the highway, the main administrative offices are located at the Neshuro Business Center. The weather is hot and dry throughout the year, except during the summer when rain is frequent. In 2002, the population of the drought-prone district was estimated to be 126,000, up by 25,000 from the 1992 drought.
Mwenezi lies in natural regions four and five.