An industrial school was founded there in 1921. In 1941, it was moved to Esigodini. The buildings were then used as an experimental sub-station of the Matopos Research Station.
- David Joseph Mfanyana Kwidini of PF-ZAPU - 29 538 votes.
- Obert Moses Mpofu of Zanu PF - 5 926 votes.
- Mtoliki Sibanda of MDC with 12 318 votes,
- Ndabazekaya Mathema of Zanu-PF with 5 634 votes,
- George Moyo of LPZ with 0 votes.
Tsholotsho was later divided into two political constituencies, Tsholotsho North and Tsholotsho South.
- Musa Ncube of Zanu PF with 4 759 votes,
- Tapson Nganunu Sibanda of CCC with 2 879 votes,
- Leonard Mthombemi of ZAPU with 868 votes,
- Bongani Moyo, Independent, with 155 votes.
According to the 2012 population census, Tsholotsho has 115 119 people.
NoViolet Bulawayo was born in the district.
Schools and Infrastructure
The constituency has 30 primary schools and 13 secondary schools comprising of 5 A’ level schools and 8 O’ level schools. Of all schools and only Tsholotsho High School offers boarding facilities whereas the rest operate as Day schools. There are 6 health centers in Tsholotsho South namely, Tsholotsho district hospital, Tsholotsho rural hospital, Madlangombe rural hospital and Makaza, Bubude, Nkunzi rural health centers. The health centres are found in wards 22, 14, 17, 19, and 10. There are 28 business centers in the constituency of which 10 centers are electrified. One business center in ward 22 has a police post, and a sub-post office. 
- Mandla Tshuma, CCC, ZANU-PF Tsholotsho South candidates woo voters, CITE, Published: February 8, 2022, Retrieved: March 22, 2022
- , Tsholotsho North, Zimbabwe Election Support Network, published: 2015, retrieved: June 21, 2016
- , Tsholotsho South Constituency Profile, Parliament of Zimbabwe, published: No Date Given, retrieved: June 21, 2016
- , Matebeleland North Provincial Report, ZimStat, published: No Date Given, retrieved: June 21, 2016
- [Katherine Sayce (Ed), Tabex, Encyclopedia Zimbabwe], Tabex, Encyclopedia Zimbabwe, (Quest Publishing, Harare, 1987), Retrieved: 25 July 2019
- [Mary Akers (ed.), Encyclopaedia Rhodesia] (The College Press, Salisbury, 1973) Retrieved 8 August 2019"